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Tambiciclib - GenFleet Therapeutics/Sellas Life Sciences

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Drug Profile

Tambiciclib - GenFleet Therapeutics/Sellas Life Sciences

Alternative Names: GFH-009; SLS 009 - Sellas Life Science Group; SLS-009 - Sellas Life Sciences Group

Latest Information Update: 27 Oct 2025

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At a glance

  • Originator GenFleet Therapeutics
  • Developer GenFleet Therapeutics; Sellas Life Sciences Group
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 9 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Peripheral T-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia
  • Phase I/II Diffuse large B cell lymphoma; Haematological malignancies; Peripheral T-cell lymphoma
  • Phase I Solid tumours
  • Preclinical Colorectal cancer; T-cell prolymphocytic leukaemia

Most Recent Events

  • 13 Oct 2025 Preclinical trials in T-cell prolymphocytic leukaemia (Combination therapy) in USA (Parenteral)
  • 13 Oct 2025 Preclinical trials in T-cell prolymphocytic leukaemia (Monotherapy) in USA (Parenteral)
  • 13 Oct 2025 Pharmacodynamics data from preclinical studies in T-cell prolymphocytic leukaemia released by SELLAS Life Sciences

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