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GTB 5550

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Drug Profile

GTB 5550

Alternative Names: B7H3 TriKE™; cam1615B7H3; camB7-H3 TriKE®; Camelid Nanobody B7-H3 Tri-Specific Killer Engager - GT Biopharma; GTB-5550; GTB-5550 TriKE™

Latest Information Update: 22 May 2026

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At a glance

  • Originator University of Minnesota
  • Developer GT Biopharma
  • Class Antineoplastics; Immunoglobulin fragments; Immunoglobulin Fv fragments; Immunotherapies; Interleukins; Recombinant fusion proteins; Single-domain antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Interleukin 15 replacements; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • Preclinical Multiple myeloma

Most Recent Events

  • 08 Apr 2026 Phase-I clinical trials in Solid tumours (Late-stage disease, Second-line therapy or greater, Metastatic disease) in USA (SC) (NCT07541573)
  • 03 Feb 2026 GT Biopharma plans a phase I dose escalation basket trial trial for GBT 5550 in Solid tumours in mid-2026
  • 03 Feb 2026 The US FDA approves IND application for GTB 5550 in Solid tumours

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