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V 181

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Drug Profile

V 181

Alternative Names: Dengue Tetravalent Vaccine; V-181

Latest Information Update: 13 Jun 2025

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At a glance

  • Originator National Institute of Allergy and Infectious Diseases
  • Developer Butantan Institute; Merck Sharp & Dohme; National Institute of Allergy and Infectious Diseases
  • Class Attenuated vaccines; Dengue vaccines
  • Mechanism of Action Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Dengue

Most Recent Events

  • 11 Jun 2025 Phase-III clinical trials in Dengue (In children, In adolescents, Prevention) in Singapore (SC) (NCT07013487)
  • 12 Dec 2024 Butantan Institute in collaboration with Merck Sharp & Dohme completes a phase II trial in Dengue (Prevention, In adults) in Brazil (SC) (NCT05710224)
  • 15 Feb 2023 Butantan Institute in collaboration with Merck Sharp & Dohme initiates a phase II trial in Dengue (Prevention, In adults) in Brazil (SC) (NCT05710224)

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