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Icotrokinra - Janssen Biotech

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Drug Profile

Icotrokinra - Janssen Biotech

Alternative Names: JNJ 77242113; JNJ-2113; PN-21235; PN-235

Latest Information Update: 10 Oct 2025

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At a glance

  • Originator Protagonist Therapeutics
  • Developer Janssen Biotech
  • Class Amides; Anti-inflammatories; Antipsoriatics; Antirheumatics; Butyric acids; Disulfides; Ethanolamines; Indoles; Naphthalenes; Pentanoic acids; Peptides; Phenyl ethers; Pyridines; Sulfhydryl compounds
  • Mechanism of Action Interleukin-23 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Plaque psoriasis
  • Phase III Erythrodermic psoriasis; Generalised pustular psoriasis; Psoriatic arthritis
  • Phase II Ulcerative colitis
  • Phase I Inflammation

Most Recent Events

  • 07 Oct 2025 Efficacy data from a phase II trial in Ulcerative colitis released by Johnson & Johnson
  • 29 Sep 2025 Janssen Research & Development LLC plans a phase III trial for Ulcerative colitis (Mid-stage disease, In adults, In adolescent, In children, Treatment-resistant) in USA (PO) in October 2025 (NCT07196748)
  • 29 Sep 2025 Janssen Research & Development LLC plans a phase II/III trial for Crohn's disease (Mid-stage disease, Treatment-resistant) in USA (PO) in October 2025 (NCT07196722)

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