Drug Profile

BMS 986446

Alternative Names: Anti-tau antibody - Prothena; BMS-986446; PRX 005

Latest Information Update: 08 May 2025

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At a glance

Originator Prothena
Developer Bristol-Myers Squibb; Prothena
Class Antidementias; Monoclonal antibodies; Neuroprotectants
Mechanism of Action Tau protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Alzheimer's disease

Most Recent Events

06 May 2025 Bristol Myers Squibb plans a phase I pharmacokinetic trial (In volunteers) in USA in May 2025 (IV) (SC) (NCT06955741)
05 May 2025 Bristol-Myers Squibb initiates a phase I pharmacokinetic trial (In volunteers) in the US (IV) (NCT06955741)
08 Aug 2024 Phase-II clinical trials in Alzheimer's disease in Australia, Canada, Japan (SC) (NCT06268886)

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