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WVE 006

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Drug Profile

WVE 006

Alternative Names: AIMers; GSK-5462688; SERPINA1 stereopure nucleic acid therapeutic - WaVe Life Sciences; WVE-006

Latest Information Update: 05 Feb 2026

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At a glance

  • Originator WaVe life Sciences
  • Class Amides; Amino sugars; Drug conjugates; Oligonucleotides
  • Mechanism of Action Gene expression modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Alpha 1-antitrypsin deficiency

Most Recent Events

  • 02 Feb 2026 WVE 006 is no longer licensed to GSK in Workd
  • 02 Feb 2026 Wave Life Sciences plans to advance the registrational strategy for WVE 006, with US FDA feedback on a potential accelerated approval pathway expected by mid 2026
  • 06 Nov 2025 Efficacy data from phase Ib/IIa RestorAATion-2 trial in Alpha-1 antitrypsin deficiency released by Wave Life Sciences

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