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WVE 006

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Drug Profile

WVE 006

Alternative Names: AIMers; GSK-5462688; SERPINA1 stereopure nucleic acid therapeutic - WaVe Life Sciences; WVE-006

Latest Information Update: 31 Aug 2026

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At a glance

  • Originator WaVe life Sciences
  • Class Amides; Amino sugars; Drug conjugates; Oligonucleotides
  • Mechanism of Action SERPINA1 protein expression modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Alpha 1-antitrypsin deficiency

Most Recent Events

  • 30 Jul 2026 Wave Life Sciences plans to meet with the US FDA to discuss a potential accelerated approval pathway for WVE 006 by mid of 2026
  • 18 May 2026 Efficacy and adverse evenst data from a phase I RestorAATion-1 trial for Alpha 1-antitrypsin deficiency released by WaVe life Sciences
  • 02 Feb 2026 WVE 006 is no longer licensed to GSK in Workd

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