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WVE 006

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Drug Profile

WVE 006

Alternative Names: AIMers; GSK-5462688; SERPINA1 stereopure nucleic acid therapeutic - WaVe Life Sciences; WVE-006

Latest Information Update: 23 May 2025

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At a glance

  • Originator WaVe life Sciences
  • Class Amides; Amino sugars; Drug conjugates; Oligonucleotides
  • Mechanism of Action SERPINA1 protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Alpha 1-antitrypsin deficiency

Most Recent Events

  • 13 Feb 2025 WaVe life Sciences completes a phase I RestorAATion-1 trial for Alpha 1-antitrypsin deficiency(In volunteers) in UK (SC, Injection) (NCT06186492)
  • 15 Nov 2024 Pharmacodynamics data from a preclinical study in Alpha-1 antitrypsin deficiency presented at the 75th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2024)
  • 16 Oct 2024 Adverse events data from phase-I RestorAATion-1 trial in Alpha-1 antitrypsin deficiency (In volunteers) released by Wave Life Sciences

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