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AFM 28

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Drug Profile

AFM 28

Alternative Names: AFM-28

Latest Information Update: 18 Aug 2025

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At a glance

  • Originator Affimed Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia
  • Preclinical Myelodysplastic syndromes

Most Recent Events

  • 18 Jul 2025 Affimed GmbH terminates phase I clinical trials in Acute myeloid leukaemia (Monotherapy, Second-line therapy or greater) in France and Spain (IV) due to sponsor decision (NCT05817058)
  • 28 May 2025 No recent reports of development identified for preclinical development in Acute-myeloid-leukaemia in Germany (Parenteral)
  • 07 Dec 2024 Pharmacodynamics data from a preclinical trial in Acute myeloid leukaemia and Myelodysplastic syndromes presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)

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