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Mebufotenin - GH Research

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Drug Profile

Mebufotenin - GH Research

Alternative Names: 5 Methoxy N N dimethyltryptamine - GH Research; 5 Methoxy N,N Dimethyltryptamine; 5-MeO-DMT; GH-001; GH-002; GH-003

Latest Information Update: 25 Jun 2025

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At a glance

  • Originator GH Research
  • Class Antidepressants; Behavioural disorder therapies; Ethers; Mood stabilisers; Small molecules; Tryptamines
  • Mechanism of Action Serotonin receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bipolar disorders; Major depressive disorder; Postnatal depression

Most Recent Events

  • 20 Jun 2025 GH Research submits full response to the IND hold in Major depressive disorder
  • 11 Mar 2025 GH Research completes a phase II trial in Major depressive disorder (Treatment-resistant) in Czech Republic, Germany, Ireland, Netherlands, Poland and Spain (Inhalation, Aerosol) (NCT05800860)
  • 27 Feb 2025 Efficacy and adverse events data from phase II clinical trials in Major depressive disorder released by GH Research

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