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Saruparib - AstraZeneca

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Drug Profile

Saruparib - AstraZeneca

Alternative Names: AZD-5305

Latest Information Update: 28 Sep 2026

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At a glance

  • Originator AstraZeneca
  • Class Amides; Antineoplastics; Naphthyridines; Piperazines; Pyridines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Prostate cancer
  • Phase II Pancreatic cancer; Solid tumours
  • Phase I/II Ovarian cancer

Most Recent Events

  • 22 Sep 2026 Abramson Cancer Center at Penn Medicine in collaboration with AstraZeneca plans a phase II trial for Solid Tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in the USA (PO) in November 2026 (NCT07832630)
  • 17 Jul 2026 AstraZeneca plans a phase III EvoPAR-PR05 trial for Prostate cancer (Combination therapy, Metastatic disease, Recurrent, Second-line therapy or greater) in Canada (PO) in October 2026 (NCT07711002)
  • 15 Jun 2026 AstraZeneca completes a phase-I trial in Prostate cancer (Combination therapy, Monotherapy, First-line therapy) in Netherlands, Spain, United Kingdom, USA (PO) (NCT05938270)

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