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Saruparib - AstraZeneca

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Drug Profile

Saruparib - AstraZeneca

Alternative Names: AZD-5305

Latest Information Update: 05 Mar 2026

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At a glance

  • Originator AstraZeneca
  • Class Amides; Antineoplastics; Naphthyridines; Piperazines; Pyridines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Prostate cancer
  • Phase II Solid tumours
  • Phase I/II Ovarian cancer

Most Recent Events

  • 18 Feb 2026 AstraZeneca terminates a phase I/II trial in Ovarian cancer (Recurrent, Late-stage disease, First-line therapy) in Spain, South Korea, Italy, USA (PO) prior to enrollment (NCT07060365)
  • 27 Jan 2026 Phase-I/II clinical trials in Prostate cancer (Combination therapy, Metastatic disease) in Japan, USA (PO) (NCT07336446)
  • 27 Jan 2026 AstraZeneca initiates enrolment in the Phase-I/II ANDROMEDA trial in Prostate cancer (Combination therapy, Metastatic disease) in Australia and United Kingdom (PO) (NCT07336446)

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