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Saruparib - AstraZeneca

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Drug Profile

Saruparib - AstraZeneca

Alternative Names: AZD-5305

Latest Information Update: 08 May 2025

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At a glance

  • Originator AstraZeneca
  • Class Amides; Antineoplastics; Naphthyridines; Piperazines; Pyridines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Prostate cancer
  • Phase II Solid tumours

Most Recent Events

  • 01 May 2025 AstraZeneca plans a phase III trial for Prostate cancer (Late-stage disease, Newly-diagnosed, Adjuvant therapy) in Austria, Belgium, Brazil, Canada, Finland, France, Germany, Italy, Peru, Poland, Sweden, Thailand, United States (PO) (NCT06952803)
  • 25 Apr 2025 Pharmacodynamics data from preclinical trial in Prostate cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 25 Mar 2025 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Moldova, Romania, Bulgaria (PO) (NCT06899061)

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