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Muzastotug - Adagene

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Drug Profile

Muzastotug - Adagene

Alternative Names: ADG-126; Anti-CTLA-4 monoclonal antibody; Masked anti-CTLA-4 SAFEbody

Latest Information Update: 25 Aug 2025

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At a glance

  • Originator Adagene
  • Developer Adagene; Roche
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer
  • Phase I/II Liver cancer; Solid tumours

Most Recent Events

  • 12 Aug 2025 Adagene plans a phase II trial for Colorectal cancer in the second half of 2025
  • 12 Aug 2025 Adagene plans a phase III trial for Colorectal cancer in the second half of 2025
  • 01 Jul 2025 Adagene plans a phase I/II trial in Solid tumours (Combination therapy, Late-stage disease) (IV)

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