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Muzastotug - Adagene

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Drug Profile

Muzastotug - Adagene

Alternative Names: ADG-126; Anti-CTLA-4 monoclonal antibody; Anti-CTLA-4 Monoclonal Antibody ADG126; Anti-CTLA-4 SAFEbody ADG126; Masked anti-CTLA-4 SAFEbody

Latest Information Update: 24 Aug 2026

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At a glance

  • Originator Adagene
  • Developer Adagene; Roche; Sanofi
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Solid tumours
  • Phase I/II Liver cancer

Most Recent Events

  • 12 Aug 2026 Phase-I/II clinical trials in Solid tumours (Combination therapy, Late-stage disease) (Parenteral)
  • 12 Aug 2026 Adagene and Incyte plans a phase I trial for Colorectal cancer (Combination therapy, Second-line therapy or greater) later this year
  • 18 Apr 2026 Efficacy and adverse event data from a phase I/II trial in Liver cancer released by Adagene

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