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Muzastotug - Adagene

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Drug Profile

Muzastotug - Adagene

Alternative Names: ADG-126; Anti-CTLA-4 monoclonal antibody; Masked anti-CTLA-4 SAFEbody

Latest Information Update: 05 Jun 2025

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At a glance

  • Originator Adagene
  • Developer Adagene; Roche
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Liver cancer; Solid tumours

Most Recent Events

  • 22 May 2025 Updated efficacy data from the phase Ib/II trial in Solid tumours released by Adagene
  • 28 Apr 2025 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia (IV, Infusion)
  • 24 Mar 2025 Adagene plans to conduct end of phase I meeting with FDA by third quarter of 2025

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