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Camibirstat - Foghorn Therapeutics

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Drug Profile

Camibirstat - Foghorn Therapeutics

Alternative Names: FHD-286

Latest Information Update: 16 Feb 2026

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At a glance

  • Originator Foghorn Therapeutics
  • Developer Foghorn Therapeutics; Montefiore Medical Center; Yatiri Bio
  • Class Amides; Amines; Antineoplastics; Morpholines; Pyridines; Pyrroles; Small molecules; Thiazoles
  • Mechanism of Action SMARCA2 protein inhibitors; SMARCA4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes
  • Discontinued Non-small cell lung cancer; Uveal melanoma

Most Recent Events

  • 10 Feb 2026 Yatiri Bio and Foghorn Therapeutics enters into collaboration agreement for Camibirstat
  • 10 Feb 2026 Phase-I clinical trials in Acute myeloid leukaemia (In the elderly, Combination therapy, In adolescents, Second-line therapy or greater, In adults) in USA (PO)
  • 10 Feb 2026 Phase-I clinical trials in Acute myeloid leukaemia (Second-line therapy or greater, Monotherapy, Late-stage disease) in USA (PO)

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