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Ulviprubart - Abcuro

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Drug Profile

Ulviprubart - Abcuro

Alternative Names: ABC-008; Anti-KLRG1 antibody - Abcuro

Latest Information Update: 27 Feb 2026

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At a glance

  • Originator Abcuro
  • Class Anti-inflammatories; Antibodies; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; C-type lectin antagonists; Immunologic receptor antagonists; NK cell lectin-like receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Inclusion body myositis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Inclusion body myositis
  • Phase I/II Large granular lymphocytic leukaemia
  • Preclinical Non-Hodgkin's lymphoma
  • No development reported Autoimmune disorders

Most Recent Events

  • 24 Feb 2026 Efficacy and adverse events data from a phase II/III MUSCLE trial in Inclusion muscle myositis released by Abcuro
  • 09 Dec 2025 Pharmacodynamics and adverse events data from a phase-I/II trial in Large granular lymphocytic leukaemia released by Abcuro
  • 06 Dec 2025 Interim pharmacodynamics and adverse events data from a phase I/II trial in Large granular lymphocytic leukaemia presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)

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