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Recombinant crisantaspase - Jazz Pharmaceuticals/Primrose Bio

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Drug Profile

Recombinant crisantaspase - Jazz Pharmaceuticals/Primrose Bio

Alternative Names: Asparaginase Erwinia chrysanthemi (recombinant)-rywn; Asparaginase Erwinia chrysanthemi-rywn; Enrylaze; JZP-458; PF-743; Recombinant Asparginase Erwinia chrysanthemi - Jazz Pharmaceuticals/Primrose Bio; Recombinant Erwinia asparaginase - Jazz Pharmaceuticals/Primrose Bio; Rylaze

Latest Information Update: 13 Jul 2024

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At a glance

  • Originator Pfenex
  • Developer Jazz Pharmaceuticals plc
  • Class Amidohydrolases; Antineoplastics; Cytostatics; Recombinant proteins
  • Mechanism of Action Asparaginase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 31 May 2024 Updated adverse events data from a phase II/III trial in Precursor cell lymphoblastic leukaemia presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 09 Dec 2023 Efficacy, adverse events and pharmacokinetics datafrom a phase II/III trial in Precursor cell lymphoblastic leukaemia-presented at 65th American Society of Hematology Annual Meeting and Exposition 2023 (ASH-Hem-2023)
  • 22 Sep 2023 Registered for Precursor cell lymphoblastic leukaemia-lymphoma (In infants, In adolescents, In children, In adults, Combination therapy) in European Union, Iceland, Norway, Liechtenstein
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