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Dencatistat - Step Pharma

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Drug Profile

Dencatistat - Step Pharma

Alternative Names: CTPS1 inhibitor - Step Pharma; STP 938

Latest Information Update: 24 Jun 2026

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At a glance

  • Originator Step Pharma
  • Class Amines; Anti-inflammatories; Antineoplastics; Antirheumatics; Antithrombotics; Cyclopropanes; Ketones; Pyrazines; Pyridines; Pyrimidines; Small molecules; Sulfones
  • Mechanism of Action CTPS1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - T-cell lymphoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Essential thrombocythaemia
  • Phase I/II B-cell lymphoma; T-cell lymphoma
  • Phase I Solid tumours
  • Preclinical Graft-versus-host disease; Inflammation
  • No development reported Rheumatoid arthritis

Most Recent Events

  • 17 Jun 2026 Phase-II clinical trials in Essential thrombocythaemia (Treatment-experienced) in United Kingdom, France (PO)
  • 17 Jun 2026 Step Pharma plans a phase III trial for Essential thrombocythaemia in 2028
  • 23 Feb 2026 Step Pharma plans phase II trials for Gynaecological cancer

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