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Dencatistat - Step Pharma

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Drug Profile

Dencatistat - Step Pharma

Alternative Names: CTPS1 inhibitor - Step Pharma; STP 938

Latest Information Update: 06 Jun 2025

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At a glance

  • Originator Step Pharma
  • Class Anti-inflammatories; Antineoplastics; Antirheumatics; Small molecules
  • Mechanism of Action Cytidine triphosphate synthetase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - T-cell lymphoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II B-cell lymphoma; T-cell lymphoma
  • Phase I Solid tumours
  • Preclinical Graft-versus-host disease; Inflammation; Rheumatoid arthritis

Most Recent Events

  • 22 May 2025 Dencatistat receives Orphan Drug status for T-cell lymphoma in USA
  • 22 Jan 2025 Step Pharma plans a phase I trial for Essential thrombocythaemia (Treatment resistant) in the United Kingdom (PO) in first half of 2025 (NCT06786234)
  • 02 Aug 2024 Phase-I clinical trials in Solid tumours (Monotherapy, Late-stage disease) in USA (PO) (NCT06297525)

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