GSK 5926371
Alternative Names: 1A46; Anti CD19-CD20-CD3 trispecific antibody - GSK; BR-110; CMG-1A46; GSK-5926371Latest Information Update: 04 Jun 2026
At a glance
- Originator Chimagen Biosciences
- Developer BioRay Pharmaceutical; Chimagen Biosciences; GSK
- Class Antineoplastics; Immunotherapies; Trispecific antibodies
- Mechanism of Action Cytotoxic T lymphocyte stimulants; Immunologic cytotoxicity
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Orphan Drug Status
No
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase I/II Lymphoid leukaemia; Non-Hodgkin's lymphoma
- Phase I Autoimmune disorders
Most Recent Events
- 27 May 2026 GlaxoSmithKline plans a phase I/II trial for B cell lymphoma (Second-line therapy or greater), in June 2026 (NCT07607925)
- 10 Feb 2026 Phase-I clinical trials in Autoimmune disorders in Japan (IV) (NCT07371468)
- 11 Feb 2025 Chimagen Biosciences terminates phase-I/II clinical trials in Non-Hodgkin's lymphoma and Lymphoid leukaemia (Late-stage disease, Refractory metastatic disease, Second-line therapy or greater) in USA (Parenteral) due to sponsor's research and development strategy adjustment(NCT05348889)