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CMG 1A46

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Drug Profile

CMG 1A46

Alternative Names: 1A46; BR-110; CMG-1A46

Latest Information Update: 28 Feb 2025

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At a glance

  • Originator Chimagen Biosciences
  • Developer BioRay Pharmaceutical; Chimagen Biosciences; GSK
  • Class Antineoplastics; Immunotherapies; Trispecific antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Lymphoid leukaemia; Non-Hodgkin's lymphoma
  • Preclinical Autoimmune disorders

Most Recent Events

  • 11 Feb 2025 Chimagen Biosciences terminates phase-I/II clinical trials in Non-Hodgkin's lymphoma and Lymphoid leukaemia (Late-stage disease, Refractory metastatic disease, Second-line therapy or greater) in USA (Parenteral) due to sponsor's research and development strategy adjustment(NCT05348889)
  • 01 Nov 2024 BioRay Pharmaceutical terminates phase I/II trial in Non-Hodgkin's lymphoma (Second-line therapy or greater) in China (IV-injection), due to sponsor's R&D strategy adjustment (NCT05987605)
  • 29 Oct 2024 GSK acquires CMG 1A46 from Chimagen Biosciences

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