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Opnurasib - Novartis

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Drug Profile

Opnurasib - Novartis

Alternative Names: JDQ-443

Latest Information Update: 10 Jun 2024

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At a glance

  • Originator Novartis
  • Class Antineoplastics; Azetidines; Chlorobenzenes; Indazoles; Ketones; Pyrazoles; Small molecules; Spiro compounds
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase I/II Solid tumours
  • Phase I Small cell lung cancer

Most Recent Events

  • 29 May 2024 Novartis withdraws a phase II trial prior to enrollment in Non small cell lung cancer (Metastatic disease) (NCT05999357) (EudraCT2023-505721-13-00)
  • 01 Mar 2024 Novartis reinitiates an enrollment in phase I trial in participants with Hepatic impairment in USA (PO) (NCT05329623)
  • 09 Sep 2023 Efficacy and adverse events data from a phase Ib/II KontRASt-01 trial in Solid tumours presented at the 24th World Conference on Lung Cancer

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