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Daraxonrasib - REVOLUTION Medicines

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Drug Profile

Daraxonrasib - REVOLUTION Medicines

Alternative Names: RAS(ON) inhibitor- REVOLUTION Medicines; Ras-IN-2; RASMULTI(ON) Inhibitor - REVOLUTION Medicines; RMC-6236

Latest Information Update: 06 Mar 2026

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At a glance

  • Originator REVOLUTION Medicines
  • Developer Kura Oncology; REVOLUTION Medicines
  • Class Amides; Antineoplastics; Cyclopropanes; Heterocyclic compounds with 4 or more rings; Indoles; Ketones; Methyl ethers; Piperazines; Pyridazines; Pyridines; Small molecules; Thiazoles
  • Mechanism of Action Ras protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Adenocarcinoma; Non-small cell lung cancer
  • Phase I/II Pancreatic cancer; Solid tumours
  • Preclinical Colorectal cancer

Most Recent Events

  • 26 Feb 2026 Revolution Medicines plans the phase III RASolute 309 trial in Pancreatic ductal adenocarcinoma (Combination therapy, First-line therapy) in second half of 2026
  • 26 Feb 2026 Revolution Medicines plans three phase III trial 2026
  • 30 Jan 2026 Phase-I/II clinical trials in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA (PO) (NCT07397338)

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