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Daraxonrasib - REVOLUTION Medicines

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Drug Profile

Daraxonrasib - REVOLUTION Medicines

Alternative Names: RAS(ON) inhibitor- REVOLUTION Medicines; Ras-IN-2; RASMULTI(ON) Inhibitor - REVOLUTION Medicines; RMC-6236

Latest Information Update: 04 Jul 2025

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At a glance

  • Originator REVOLUTION Medicines
  • Developer Kura Oncology; REVOLUTION Medicines
  • Class Antineoplastics; Indoles; Piperazines; Pyridazines; Small molecules; Thiazoles
  • Mechanism of Action Ras protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Adenocarcinoma; Non-small cell lung cancer
  • Phase I/II Pancreatic cancer
  • Phase I Solid tumours
  • No development reported Colorectal cancer

Most Recent Events

  • 30 Jun 2025 Revolution Medicines and Summit Therapeutics agree to co-develop Daraxonrasib for Solid tumours
  • 23 Jun 2025 Daraxonrasib - REVOLUTION Medicines receives Breakthrough Therapy status for Pancreatic cancer (Second-line therapy or greater, Metastatic disease) in USA
  • 07 May 2025 Clinical trials in Non-small cell lung cancer (First-line therapy, Combination therapy, Metastatic disease) (PO) prior to May 2025

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