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LX 2006

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Drug Profile

LX 2006

Alternative Names: AAVrh.10hFXN; LX-2006

Latest Information Update: 19 Aug 2026

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At a glance

  • Originator Weill Cornell Medicine
  • Developer LEXEO Therapeutics
  • Class Cardiovascular therapies; Gene therapies
  • Mechanism of Action Frataxin protein replacements; Gene transference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Friedreich's ataxia
  • New Molecular Entity No

Highest Development Phases

  • Phase II Cardiomyopathies; Friedreich's ataxia

Most Recent Events

  • 12 Aug 2026 LEXEO Therapeutics plans to submit BLA under accelerated approval pathway for LX 2006 in first half of 2028
  • 25 Jun 2026 Phase-II clinical trials in Cardiomyopathies (In children, In adolescents, In adults, In the elderly) in USA (Parenteral) (NCT07721025)
  • 25 Jun 2026 Phase-II clinical trials in Friedreich's ataxia (In adolescents, In adults, In children, In the elderly) in USA (Parenteral) (NCT07721025)

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