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HC 5404

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Drug Profile

HC 5404

Alternative Names: HC-5404; HC-5404-FU; PERK inhibitor - HiberCell

Latest Information Update: 11 Jun 2026

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At a glance

  • Originator HiberCell
  • Class Alcohols; Amides; Amines; Antineoplastics; Fluorocarbons; Pyridines; Small molecules
  • Mechanism of Action EIF-2 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Gastric cancer; Renal cell carcinoma
  • No development reported Breast cancer; Small cell lung cancer

Most Recent Events

  • 11 Jun 2026 HC-5404 is still in phase I trial for Gastric cancer (Monotherapy, Combination therapy) in USA (HiberCell pipeline, June 2026)
  • 11 Jun 2026 HC-5404 is still in phase I trial for Renal cell carcinoma (Monotherapy, Combination therapy) in USA (HiberCell pipeline, June 2026)
  • 04 Jun 2026 HiberCell plans a phase Ib/II trial for Renal cell carcinoma and Gastric cancer (Combination therapy) (HiberCell pipeline, June 2026)

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