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Ogalvibart/C 144LS

Drug Profile

Ogalvibart/C 144LS

Alternative Names: Anti-SARS-CoV-2 mAbs - Bristol Myers Squibb; BMS-986414+BMS-986413; BMS-986414/C 144LS; C 144LS/BMS-986414; C 144LS/IM051; C 144LS/ogalvibart; C-135-LS/C-144-LS; C-144-LS/C-135-LS; COVID-19 mAbs - Bristol Myers Squibb; IM051/C 144LS; Monoclonal antibody duo - Bristol Myers Squibb; SARS-CoV-2 neutralising monoclonal antibody combination - Bristol Myers Squibb

Latest Information Update: 11 Aug 2023

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At a glance

  • Originator Rockefeller University
  • Developer National Institute of Allergy and Infectious Diseases; Rockefeller University; Xencor
  • Class Antivirals; Monoclonal antibodies
  • Mechanism of Action Virus internalisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III COVID 2019 infections

Most Recent Events

  • 20 Jun 2023 National Institute of Allergy and Infectious Diseases (NIAID) completes phase-II/III ACTIV-2 trial in COVID-2019 infections in USA, Argentina, Brazil, Canada, South Africa, Mexico, Philippines and Puerto Rico (Inhalation) (NCT04518410)
  • 02 Aug 2022 Rockefeller University completes a phase I trial (In volunteers) in COVID-2019 infections (IV, SC) in USA (NCT04700163)
  • 10 Mar 2022 Bristol-Myers Squibb completes enrolment in its phase II trial for COVID-2019 infections (Prevention) in the US (Bristol-Myers Squibb 10-K, December 2021)
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