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SAGE 421

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Drug Profile

SAGE 421

Alternative Names: SAGE-421

Latest Information Update: 28 May 2026

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At a glance

  • Originator SAGE Therapeutics
  • Class Neuroprotectants; Nootropics; Small molecules; Sterols
  • Mechanism of Action NMDA receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • No development reported Cognition disorders; Neurodevelopmental disorders

Most Recent Events

  • 28 May 2026 No recent reports of development identified for phase-I development in Cognition-disorders in Unknown (PO)
  • 28 Mar 2026 No recent reports of development identified for preclinical development in Neurodevelopmental-disorders in USA (PO)
  • 31 Jul 2025 SAGE Therapeutics has been acquired by Supernus Pharmaceuticals

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