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Pembrolizumab/vibostolimab - Merck

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Drug Profile

Pembrolizumab/vibostolimab - Merck

Alternative Names: Coformulation pembrolizumab/vibostolimab - Merck Sharp & Dohme; MK-7684A; Pembrolizumab+vibostolimab; Vibostolimab+pembrolizumab; Vibostolimab/pembrolizumab - Merck Sharp & Dohme

Latest Information Update: 04 Mar 2026

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antineoplastics; Antivirals; Immunotherapies; Monoclonal antibodies; Tumour-agnostic therapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants; TIGIT protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Adenocarcinoma; Biliary cancer; Bladder cancer; Colorectal cancer; Endometrial cancer; Gallbladder cancer; Gastric cancer; Haematological malignancies; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Renal cell carcinoma; Small cell lung cancer; Triple negative breast cancer

Most Recent Events

  • 04 Mar 2026 Merck Sharp & Dohme completes the phase-III MK-7684A-003, KEYVIBE-003 trial in Non-small cell lung cancer (Combination therapy, First-line therapy, Metastatic disease, Monotherapy) in Vietnam, USA, Turkey, Ukraine, Thailand, South Africa, Russia, Romania, Philippines, Peru, Mexico, Malaysia, South Korea, Japan, India, Hong Kong, Guatemala, Dominican Republic, China, Chile, Canada, Brazil (IV, Infusion) (NCT04738487)
  • 05 Aug 2025 Merck Sharp & Dohme completes a phase II trial in Endometrial cancer, Uterine cancer, Head and neck cancer, Gallbladder cancer, Biliary cancer, Endometrial cancer, Oesophageal cancer, Triple-negative-breast cancer, Liver cancer, Ovarian cancer (Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Taiwan, Turkey, Spain, Netherlands, Japan, Poland, Netherlands, South Korea, Italy, France, Canada, Canada, USA, Chile, Germany, Israel (IV) (NCT05007106) (EudraCT2021-001009-56)
  • 16 Dec 2024 Efficacy and adverse events data from the phase III KeyVibe-003 and phase III KeyVibe-007 trials in Non-small cell lung cancer released by Merck

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