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Pembrolizumab/vibostolimab - Merck

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Drug Profile

Pembrolizumab/vibostolimab - Merck

Alternative Names: Coformulation pembrolizumab/vibostolimab - Merck Sharp & Dohme; MK-7684A; Pembrolizumab+vibostolimab; Vibostolimab+pembrolizumab; Vibostolimab/pembrolizumab - Merck Sharp & Dohme

Latest Information Update: 29 Dec 2024

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antineoplastics; Antivirals; Immunotherapies; Monoclonal antibodies; Tumour-agnostic therapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants; TIGIT protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Adenocarcinoma; Biliary cancer; Bladder cancer; Colorectal cancer; Endometrial cancer; Gallbladder cancer; Gastric cancer; Haematological malignancies; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Renal cell carcinoma; Small cell lung cancer; Triple negative breast cancer

Most Recent Events

  • 16 Dec 2024 Efficacy and adverse events data from the phase III KeyVibe-003 and phase III KeyVibe-007 trials in Non-small cell lung cancer released by Merck
  • 16 Dec 2024 Discontinued - Phase-II for Triple-negative-breast-cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Turkey, Taiwan, Spain, Spain, Poland, Netherlands, South Korea, Japan, Italy, Israel, Germany, France, Chile, Canada, USA (IV)
  • 16 Dec 2024 Discontinued - Phase-I/II for Adenocarcinoma (Combination therapy, Hormone refractory) in Turkey, Taiwan, Sweden, Spain, Poland, New Zealand, Netherlands, Mexico, Italy, Ireland, Germany, Finland, Denmark, Austria, Australia, United Kingdom, France, Canada, USA (IV)

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