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CYB 004

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Drug Profile

CYB 004

Alternative Names: CYB-004; dDMT - Cybin; Deuterated dimethyltryptamine - Cybin; HLP-004

Latest Information Update: 16 Mar 2026

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At a glance

  • Originator Cybin
  • Class Antidepressants; Anxiolytics; Behavioural disorder therapies; Drug withdrawal therapies; Tryptamines
  • Mechanism of Action Serotonin 5-HT2 receptor agonists; Serotonin 5-HT2A receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Generalised anxiety disorder
  • Phase I Anxiety disorders; Depressive disorders
  • Discontinued Psychiatric disorders; Substance-related disorders

Most Recent Events

  • 05 Mar 2026 Topline efficacy, adverse event and pharmacokinetic data from a phase II trial in Generalised anxiety disorders released by Cybin
  • 01 Oct 2025 Phase I development is ongoing in Generalised-anxiety-disorder (In volunteers) in Netherlands (Inhalation).
  • 28 Sep 2025 No recent reports of development identified for phase-I development in Generalised-anxiety-disorder (In volunteers) in Netherlands (Inhalation)

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