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Nirmatrelvir + ritonavir - Pfizer

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Drug Profile

Nirmatrelvir + ritonavir - Pfizer

Alternative Names: nirmatrelvir [PF-07321332] tablets and ritonavir tablets; Nirmatrelvir plus ritonavir - Pfizer; Nirmatrelvir+ritonavir - Pfizer; nirmatrelvir/ritonavir; PAXLOVID; PF 07321332 plus ritonavir - Pfizer; PF 07321332+ritonavir - Pfizer; PF-07321332/ritonavir

Latest Information Update: 30 Aug 2024

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At a glance

  • Originator Pfizer
  • Class Amides; Amines; Antiretrovirals; Antivirals; Aza compounds; Carbamates; Fluorinated hydrocarbons; Heterocyclic bicyclo compounds; Nitriles; Pyrrolidinones; Small molecules; Thiazoles
  • Mechanism of Action Coronavirus 3C-like proteinase inhibitors; HIV protease inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed COVID 2019 infections

Most Recent Events

  • 19 Aug 2024 Pfizer suspends a phase I trial in COVID-2019 infections in USA (PO) to allow time for further pharmacokinetic modelling and simulation work to be performed (NCT05386472)
  • 04 Jun 2024 Pfizer re-initiates the phase II/III EPIC-PEDS trial in COVID-2019 infections (In children, In adolescents, In infants, In neonates) in USA, Bulgaria, Hungary, Mexico, South Africa, United Kingdom (PO, Tablets) (NCT05261139) (EudraCT2022-000075-39)
  • 02 May 2024 Pfizer plans a phase I trial for COVID-19 infections (In Volunteers) in 2025 (PO,Tablet) (NCT06397144)

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