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Nirmatrelvir + ritonavir - Pfizer

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Drug Profile

Nirmatrelvir + ritonavir - Pfizer

Alternative Names: nirmatrelvir [PF-07321332] tablets and ritonavir tablets; Nirmatrelvir plus ritonavir - Pfizer; Nirmatrelvir+ritonavir - Pfizer; nirmatrelvir/ritonavir; PAXLOVID; PF 07321332 plus ritonavir - Pfizer; PF 07321332+ritonavir - Pfizer; PF-07321332/ritonavir

Latest Information Update: 19 Mar 2026

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At a glance

  • Originator Pfizer
  • Class Amides; Amines; Antiretrovirals; Antivirals; Aza compounds; Carbamates; Fluorinated hydrocarbons; Heterocyclic bicyclo compounds; Nitriles; Pyrrolidinones; Small molecules; Thiazoles
  • Mechanism of Action Coronavirus 3C-like proteinase inhibitors; HIV protease inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed COVID 2019 infections

Most Recent Events

  • 31 Jan 2026 Withdrawn for COVID-2019 infections (In adolescents, In children, In the elderly, In adults) in USA (PO)
  • 26 Dec 2025 Pfizer withdraws a phase I trial (In volunteers) due to sponsor business decision to terminate study (NCT06397144)
  • 28 Oct 2025 No recent reports of development identified for phase-I development in COVID-2019-infections(In the elderly, In adults) in USA (PO, Capsule)

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