Drug Profile

Naperiglipron - Eli Lilly and Company

Alternative Names: GLP-1R NPA II - Eli Lilly; LY-3549492

Latest Information Update: 03 Apr 2026

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At a glance

Originator Eli Lilly and Company
Class Antihyperglycaemics; Obesity therapies
Mechanism of Action Glucagon-like peptide-1 receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Obesity; Type 2 diabetes mellitus

Most Recent Events

02 Mar 2026 Eli Lilly and Company completes phase I clinical trial in Type 2 diabetes mellitus (In volunteers) in Japan (PO) (NCT06869018)
27 Jan 2026 Eli Lilly and Company completes a phase I clinical trial in Type 2 diabetes mellitus in China (PO) (NCT07073170)
27 Oct 2025 Eli Lily and Company initiates a phase I trial for Obesity (In volunteers) in USA (PO) (NCT07232732)

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