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Naperiglipron - Eli Lilly

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Drug Profile

Naperiglipron - Eli Lilly

Alternative Names: GLP-1R NPA II - Eli Lilly; LY-3549492

Latest Information Update: 10 Oct 2025

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At a glance

  • Originator Eli Lilly and Company
  • Class Antihyperglycaemics; Obesity therapies
  • Mechanism of Action Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Obesity; Type 2 diabetes mellitus

Most Recent Events

  • 14 Aug 2025 Eli Lily and Company terminates a phase II trial in healthy volunteers in Canada and USA (PO) for strategic business reasons (NCT07085468)
  • 29 Jul 2025 Eli Lily terminates a phase II trial in Obesity and Type 2 diabetes mellitus in Argentina, USA (PO) due to strategic business reasons (NCT07030868)
  • 25 Jul 2025 Eli Lilly and Company plans a phase II trial in Obesity (In volunteers) in USA and Canada (PO) in August 2025 (NCT07085468)

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