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Naperiglipron - Eli Lilly and Company

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Drug Profile

Naperiglipron - Eli Lilly and Company

Alternative Names: GLP-1R NPA II - Eli Lilly; LY-3549492

Latest Information Update: 30 Jul 2026

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At a glance

  • Originator Eli Lilly and Company
  • Class Antihyperglycaemics; Benzimidazoles; Carboxylic acids; Ethers; Fluorocarbons; Obesity therapies; Pyridines; Small molecules
  • Mechanism of Action Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Obesity; Type 2 diabetes mellitus

Most Recent Events

  • 30 Jul 2026 Chemical structure information added
  • 16 Jul 2026 Eli Lily and Company completes a phase I trial for Obesity (In volunteers) in USA (PO) (NCT07232732)
  • 28 Jun 2026 No recent reports of development identified for phase-I development in Type-2-diabetes-mellitus(Combination therapy, Treatment-experienced) in Germany (PO)

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