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Naperiglipron - Eli Lilly

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Drug Profile

Naperiglipron - Eli Lilly

Alternative Names: GLP-1R NPA II - Eli Lilly; LY-3549492

Latest Information Update: 04 Aug 2025

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At a glance

  • Originator Eli Lilly and Company
  • Class Antihyperglycaemics; Obesity therapies
  • Mechanism of Action Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Obesity
  • Phase I Type 2 diabetes mellitus

Most Recent Events

  • 25 Jul 2025 Eli Lilly and Company plans a phase II trial in Obesity (In volunteers) in USA and Canada (PO) in August 2025 (NCT07085468)
  • 18 Jul 2025 Eli Lilly and Company plans a phase I trial for Type 2 diabetes mellitus in China (PO), in August 2025 (NCT07073170)
  • 28 Jun 2025 No recent reports of development identified for phase-I development in Type-2-diabetes-mellitus(Combination therapy, Treatment-experienced) in Germany (PO)

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