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Lepodisiran - Eli Lilly and Company

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Drug Profile

Lepodisiran - Eli Lilly and Company

Alternative Names: DCR-CM2; LP(a)-siRNA - Eli Lilly and Company; LY 3819469

Latest Information Update: 04 Jul 2024

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At a glance

  • Originator Dicerna Pharmaceuticals
  • Developer Dicerna Pharmaceuticals; Eli Lilly and Company
  • Class Amides; Amino sugars; Antihyperlipidaemics; Cardiovascular therapies; Drug conjugates; Pyrrolidines; Small interfering RNA
  • Mechanism of Action Lipoprotein A expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hyperlipoproteinaemia

Most Recent Events

  • 05 Mar 2024 Phase-III clinical trials in Hyperlipoproteinaemia in United Kingdom, Taiwan, Slovakia, Puerto Rico, Poland, South Korea, Italy, Israel, Hungary, Greece, France, Czech Republic, Canada, Brazil, Belgium, Austria, Australia, Argentina, Romania, Spain, Japan, Netherlands, Mexico, China, Germany, Denmark, USA (SC) (NCT06292013)
  • 09 Jan 2024 Eli lily and company completes a phase I trial pharmacokinetics trial (In volunteers) in USA (SC) (NCT05841277)
  • 11 Nov 2023 Pharmacokinetics and adverse events data from a phase I trial presented at the American Heart Association Scientific Sessions 2023 (AHA-2023)

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