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DNL 111

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Drug Profile

DNL 111

Alternative Names: DNL-111; ETV-GBA; ETV:Gcase

Latest Information Update: 22 Jan 2025

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At a glance

  • Originator Denali Therapeutics Inc
  • Class Antiparkinsonians; Glucosidases; Recombinant fusion proteins
  • Mechanism of Action Glucosylceramidase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Gaucher's disease; Parkinson's disease

Most Recent Events

  • 13 Jan 2025 Preclinical trials in Gaucher's disease in USA (Parenteral), prior to January 2025
  • 13 Jan 2025 Preclinical trials in Parkinson's disease in USA (Parenteral), prior to January 2025
  • 25 Feb 2021 ETV GBA is available for licensing as of 25 Feb 2021. https://www.denalitherapeutics.com/partnering

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