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DNL 952

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Drug Profile

DNL 952

Alternative Names: DNL-952; ETV GAA

Latest Information Update: 24 Nov 2025

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At a glance

  • Originator Denali Therapeutics Inc
  • Class Alpha-glucosidases; Recombinant fusion proteins
  • Mechanism of Action Alpha-glucosidase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Glycogen storage disease type II

Most Recent Events

  • 07 Nov 2025 Denali Therapeutics plans a clinical study for Pompe disease
  • 31 Oct 2025 Denali Therapeutics submits an investigational new drug application for DNL 952 for Pompe disease
  • 13 Jan 2025 Preclinical trials in Glycogen storage disease type II in USA (Parenteral), prior to January 2025

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