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DNL 952

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Drug Profile

DNL 952

Alternative Names: DNL-952; ETV GAA

Latest Information Update: 18 May 2026

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At a glance

  • Originator Denali Therapeutics Inc
  • Class Alpha-glucosidases; Recombinant fusion proteins
  • Mechanism of Action Alpha-glucosidase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Glycogen storage disease type II

Most Recent Events

  • 12 May 2026 Phase-I clinical trials in Glycogen storage disease type II in USA (Parenteral) (NCT07354724)
  • 09 Mar 2026 Denali Therapeutics submitted a CTA application for DNl 952 in United Kingdom and Europe
  • 21 Jan 2026 Denali Therapeutics plans to initiate a phase I trial for Glycogen storage disease type II (IV) in March 2026 (NCT07354724)

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