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Melanoma-associated antigen A4-specific T-cells co-expressing CD8 alpha - Adaptimmune

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Drug Profile

Melanoma-associated antigen A4-specific T-cells co-expressing CD8 alpha - Adaptimmune

Alternative Names: ADP‑A2M4CD8; Autologous genetically modified ADP-A2M4CD8 cells; uza-cel

Latest Information Update: 13 Aug 2024

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At a glance

  • Originator Adaptimmune
  • Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Gastric cancer; Oesophageal cancer; Ovarian cancer
  • Phase I Solid tumours

Most Recent Events

  • 30 May 2024 Adaptimmune and Galapagos NV agree to co-develop Melanoma-assocaiated antigen A4-specific T-cells co-expressing CD8 alpha
  • 20 Mar 2024 Phase-I clinical trials in Solid tumours (In adults, In the elderly) in France (Parenteral) (NCT04044859)
  • 20 Mar 2024 Phase-I clinical trials in Solid tumours (In adults, In the elderly) in United Kingdom (Parenteral) (NCT04044859)

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