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Uzatresgene autoleucel - US WorldMeds

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Drug Profile

Uzatresgene autoleucel - US WorldMeds

Alternative Names: ADP-5701; ADP‑A2M4CD8; Autologous genetically modified ADP-A2M4CD8 cells; Melanoma-associated antigen A4-specific T-cells co-expressing CD8 alpha - Adaptimmune; uza-cel

Latest Information Update: 12 Aug 2025

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At a glance

  • Originator Adaptimmune
  • Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Gastric cancer; Oesophageal cancer; Ovarian cancer
  • Phase I Solid tumours

Most Recent Events

  • 04 Aug 2025 US WorldMeds acquires uzatresgene autoleucel from Adaptimmune
  • 31 Jul 2025 Adaptimmune plans clinical trial authorisation for head and neck cancer
  • 31 Jul 2025 Adaptimmune plans a phase I trial in Head and neck cancer in late 2025

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