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Melanoma-associated antigen A4-specific T-cells co-expressing CD8 alpha - Adaptimmune

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Drug Profile

Melanoma-associated antigen A4-specific T-cells co-expressing CD8 alpha - Adaptimmune

Alternative Names: ADP‑A2M4CD8; Autologous genetically modified ADP-A2M4CD8 cells; uza-cel; Uzatresgene autoleucel

Latest Information Update: 28 Mar 2025

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At a glance

  • Originator Adaptimmune
  • Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Gastric cancer; Oesophageal cancer; Ovarian cancer
  • Phase I Solid tumours

Most Recent Events

  • 28 Mar 2025 No recent reports of development identified for phase-I development in Solid-tumours(In the elderly, In adults) in Belgium (Parenteral)
  • 28 Mar 2025 No recent reports of development identified for phase-I development in Solid-tumours(In the elderly, In adults) in Canada (Parenteral)
  • 28 Mar 2025 No recent reports of development identified for phase-I development in Solid-tumours(In the elderly, In adults) in Spain (Parenteral)

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