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HCW 9218

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Drug Profile

HCW 9218

Alternative Names: Bifunctional TGF-β antagonist/IL-15 protein complex - HCW Biologics; HCW-9218

Latest Information Update: 28 Feb 2026

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At a glance

  • Originator HCW Biologics
  • Developer HCW Biologics; University of Minnesota
  • Class Antineoplastics; Hepatoprotectants; Immunotherapies; Interleukins; Recombinant fusion proteins
  • Mechanism of Action Interleukin 15 replacements; Transforming growth factor beta type II receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ovarian cancer
  • Phase I/II Pancreatic cancer
  • Research Fibrosis; Neurodegenerative disorders
  • No development reported Liver cancer; Non-alcoholic fatty liver disease; Solid tumours
  • Discontinued Lymphoma; Malignant melanoma; Pulmonary fibrosis

Most Recent Events

  • 28 Feb 2026 No recent reports of development identified for research development in Liver-cancer in USA (SC)
  • 28 Feb 2026 No recent reports of development identified for research development in Non-alcoholic-fatty-liver-disease in USA (SC)
  • 28 May 2025 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (SC, Injection)

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