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ABBV CLS 484

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Drug Profile

ABBV CLS 484

Alternative Names: ABBV-CLS-484; AC-484

Latest Information Update: 01 Jul 2025

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At a glance

  • Originator Calico
  • Developer AbbVie; Calico
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Protein tyrosine phosphatase non receptor type 1 antagonists; Protein tyrosine phosphatase non-receptor type 2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Solid tumours
  • Preclinical Acute myeloid leukaemia; Anaplastic large cell lymphoma

Most Recent Events

  • 25 Apr 2025 Pharmacodynamics data from a preclinical trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 07 Dec 2024 Preclinical trials in Anaplastic large cell lymphoma in USA (unspecified route) before December 2024
  • 07 Dec 2024 Preclinical trials in Acute myeloid leukaemia in USA (unspecified route) prior to December 2024

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