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Trophoblast antigen 2 tumour activated T-cell engager therapy - Janux Therapeutics/Merck & Co

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Drug Profile

Trophoblast antigen 2 tumour activated T-cell engager therapy - Janux Therapeutics/Merck & Co

Alternative Names: TROP2-TRACTr; Trophoblast Antigen 2 Tumour Activated T-Cell Engager therapy

Latest Information Update: 21 Aug 2025

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At a glance

  • Originator Janux Therapeutics
  • Developer Janux Therapeutics; Merck & Co
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunotherapies; Peptides; Recombinant fusion proteins
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 21 Aug 2025 Trophoblast antigen 2 tumour activated T-cell engager therapy is still in preclinical development in Solid-tumours in USA (Parenteral) (Janux Therapeutics pipeline, August 2025)
  • 28 Apr 2025 No recent reports of development identified for preclinical development in Solid-tumours in USA (Parenteral)
  • 10 Mar 2023 Janux Therapeutics announces intention to select a development candidate for its Trophoblast antigen 2 tumour activated T-cell engager therapy in 2023

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