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LY 3849891

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Drug Profile

LY 3849891

Alternative Names: LY-3849891; PNPLA3 siRNA

Latest Information Update: 23 Sep 2025

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At a glance

  • Originator Dicerna Pharmaceuticals
  • Developer Dicerna Pharmaceuticals; Eli Lilly and Company
  • Class Cardiovascular therapies; Hepatoprotectants; Small interfering RNA
  • Mechanism of Action Adiponutrin expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis
  • No development reported Cardiovascular disorders; Metabolic disorders

Most Recent Events

  • 23 Sep 2025 LY 3849891 is still in phase I development in Non-alcoholic-fatty-liver-disease in USA and Japan (SC) (NCT05395481)
  • 28 Aug 2025 No recent reports of development identified for phase-I development in Non-alcoholic-fatty-liver-disease in USA (SC)
  • 28 Dec 2022 No recent reports of development identified for preclinical development in Cardiovascular-disorders in USA (SC)

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