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JANX 008

Drug Profile

JANX 008

Alternative Names: EGFR TRACTr - Janux Therapeutics/Merck & Co; EGFR-TRACTr; Epidermal growth factor receptor tumour activated T-cell engager therapy - Janux Therapeutics/Merck & Co; JANX-008

Latest Information Update: 28 Feb 2024

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At a glance

  • Originator Janux Therapeutics
  • Class Antineoplastics; Immunoglobulin fragments; Immunotherapies; Peptides; Recombinant fusion proteins
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 26 Feb 2024 Efficacy and adverse events data from a phase Ia trial in Solid tumours released by Janux Therapeutics
  • 14 Mar 2023 Phase-I clinical trials in Solid tumours (Metastatic disease, Late-stage disease) in USA (IV) (NCT05783622)
  • 10 Mar 2023 US FDA approves IND application for JANX 008 in Solid tumors as of March 2023
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