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PYX 201

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Drug Profile

PYX 201

Alternative Names: anti-EDB; PYX-201

Latest Information Update: 28 Nov 2024

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At a glance

  • Originator Pfizer
  • Developer Pyxis Oncology
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 20 Nov 2024 Merck and Pyxis oncology enter into clinical trial collaboration agreement to develop PYX 201 in combination with pembrolizumab for Head and neck squamous cell carcinoma, HR+/HER2- breast cancer, Triple-negative breast cancer and sarcoma
  • 20 Nov 2024 Efficacy, adverse events and pharmacokinetic data from a phase I trial in Solid tumours released by Pyxis Oncology
  • 20 Nov 2024 Pyxis oncology plans clinical trial of PYX 201 for head and neck squamous cell carcinoma, HR+/HER2- breast cancer, Triple-negative breast cancer and sarcoma (Combination therapy) in 1Q25

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