SBT 101
Alternative Names: AAV9-ABCD1; AAV9-hABCD1; SBT-101 - SwanBio Therapeutics; SBT101Latest Information Update: 10 Nov 2025
At a glance
- Originator SwanBio Therapeutics
- Class Adrenoleucodystrophy gene therapies; Gene therapies
- Mechanism of Action ALDP expression stimulants; Gene transference
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Orphan Drug Status
Yes - Adrenomyeloneuropathy
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Discontinued Adrenomyeloneuropathy
Most Recent Events
- 31 Oct 2025 Discontinued - Phase-I/II for Adrenomyeloneuropathy (In the elderly, In adults) in Netherlands, USA (Intrathecal) (NCT05394064) (CTIS-2021-004410-19)
- 31 Aug 2025 SwanBio Therapeutics terminates the phase I/II PROPEL trial in adrenomyeloneuropathy in the US and Netherlands (Intrathecal) due to strategic reasons(NCT05394064)
- 16 May 2025 Updated adverse events data from a I/II PROPEL trial in adrenomyeloneuropathy released by Spur Therapeutics