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CLN 978

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Drug Profile

CLN 978

Alternative Names: CD19xCD3; CLN-978; NexGem

Latest Information Update: 25 Jun 2026

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At a glance

  • Originator Cullinan Therapeutics
  • Class Antineoplastics; Antirheumatics; Bispecific antibodies; Immunoglobulin Fc fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Immunologic cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Rheumatoid arthritis; Sjogren's syndrome; Systemic lupus erythematosus
  • Discontinued Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 10 Jun 2026 Efficacy data from a phase I trial in Rheumatoid arthritis released by Cullinan Therapeutics
  • 10 Jun 2026 Cullinan Therapeutics plans a phase IIa trial for Lupus nephritis in early 2027
  • 06 Jun 2026 Efficacy and adverse event data from the phase I OUTRACE RA trial in Rheumatoid arthritis released by Cullinan Therapeutics

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