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CLN 978

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Drug Profile

CLN 978

Alternative Names: CD19xCD3; CLN-978; NexGem

Latest Information Update: 27 Jun 2025

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At a glance

  • Originator Cullinan Therapeutics
  • Class Antineoplastics; Antirheumatics; Bispecific antibodies; Immunoglobulin Fc fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Immunologic cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Rheumatoid arthritis; Systemic lupus erythematosus
  • Preclinical Sjogren's syndrome
  • Discontinued Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 19 May 2025 Phase-I clinical trials in Rheumatoid arthritis (Treatment-resistant) in Germany (SC) (NCT06994143)
  • 08 May 2025 Cullinan Therapeutics plans a phase I trial for Sjogren's syndrome in USA and globally in the second quarter of 2025
  • 29 Apr 2025 Preclinical trials in Sjogren's syndrome in USA (Parenteral) before April 2025

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