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Casdatifan - Arcus Biosciences

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Drug Profile

Casdatifan - Arcus Biosciences

Alternative Names: AB-521; HIF-2a inhibitor - Arcus Biosciences

Latest Information Update: 17 Dec 2025

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At a glance

  • Originator Arcus Biosciences
  • Developer Arcus Biosciences; AstraZeneca
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Renal cell carcinoma
  • Phase I/II Solid tumours
  • Phase I Cancer
  • No development reported Liver cancer

Most Recent Events

  • 12 Dec 2025 Arcus Biosciences plans a phase registrational III trial for Renal cell carcinoma (First line therapy) in late 2026 (PO)
  • 28 Nov 2025 No recent reports of development identified for phase-I development in Renal-cell-carcinoma(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia (PO, Capsule)
  • 28 Nov 2025 No recent reports of development identified for phase-I development in Renal-cell-carcinoma(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in South Korea (PO, Capsule)

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