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Casdatifan - Arcus Biosciences

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Drug Profile

Casdatifan - Arcus Biosciences

Alternative Names: AB-521; HIF-2a inhibitor - Arcus Biosciences

Latest Information Update: 05 Mar 2026

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At a glance

  • Originator Arcus Biosciences
  • Developer Arcus Biosciences; AstraZeneca
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Renal cell carcinoma
  • Phase I Cancer; Solid tumours
  • No development reported Liver cancer

Most Recent Events

  • 05 Mar 2026 Phase-I development in Renal-cell-carcinoma (Monotherapy, Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) is still ongoing in USA (NCT05536141)
  • 05 Mar 2026 Phase-I development in Solid-tumours (Late-stage disease, Metastatic disease, Monotherapy, Combination Therapy, Second-line therapy or greater) is still ongoing in USA, Australia, South Korea (PO) (NCT05536141)
  • 23 Feb 2026 Updated efficacy data from the phase I/Ib trial in ARC-20 trial in Renal cell carcinoma released by Arcus Biosciences

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