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Casdatifan - Arcus Biosciences

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Drug Profile

Casdatifan - Arcus Biosciences

Alternative Names: AB-521; HIF-2a inhibitor - Arcus Biosciences

Latest Information Update: 10 Mar 2026

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At a glance

  • Originator Arcus Biosciences
  • Developer Arcus Biosciences; AstraZeneca
  • Class Alcohols; Antineoplastics; Fluorinated hydrocarbons; Fluorobenzenes; Indenes; Nitriles; Organic sulfur compounds; Small molecules; Sulfides; Tetrahydronaphthalenes
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Renal cell carcinoma
  • Phase I Cancer; Solid tumours
  • No development reported Liver cancer

Most Recent Events

  • 10 Mar 2026 Chemical structure information added.
  • 09 Mar 2026 Phase-II clinical trials in Renal cell carcinoma (Neoadjuvant therapy, Combination therapy) in USA (PO) (NCT07397611)
  • 09 Mar 2026 Phase-II clinical trials in Renal cell carcinoma (Neoadjuvant therapy, Monotherapy) in USA (PO) (NCT07397611)

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