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Casdatifan - Arcus Biosciences

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Drug Profile

Casdatifan - Arcus Biosciences

Alternative Names: AB-521; HIF-2a inhibitor - Arcus Biosciences

Latest Information Update: 13 Aug 2025

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At a glance

  • Originator Arcus Biosciences
  • Developer Arcus Biosciences; AstraZeneca
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Renal cell carcinoma
  • Phase I/II Solid tumours
  • Phase I Cancer
  • No development reported Liver cancer

Most Recent Events

  • 06 Aug 2025 Phase-III clinical trials in Renal cell carcinoma (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) (PO), prior to August 2025 (NCT07011719)
  • 06 Aug 2025 Phase-III clinical trials in Renal cell carcinoma (Combination therapy, Late-stage disease, Metastatic disease, First-line therapy, Recurrent) (PO), prior to August 2025 (NCT07000149)
  • 06 Aug 2025 Updated efficacy and adverse events data from the phase I/Ib ARC-20 trial in Renal cell carcinoma released by Arcus Biosciences

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