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Casdatifan - Arcus Biosciences

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Drug Profile

Casdatifan - Arcus Biosciences

Alternative Names: AB-521; HIF-2a inhibitor - Arcus Biosciences

Latest Information Update: 26 Aug 2026

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At a glance

  • Originator Arcus Biosciences
  • Developer Arcus Biosciences; AstraZeneca
  • Class Alcohols; Antineoplastics; Fluorinated hydrocarbons; Fluorobenzenes; Indenes; Nitriles; Organic sulfur compounds; Small molecules; Sulfides; Tetrahydronaphthalenes
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Renal cell carcinoma
  • Phase I Cancer; Solid tumours
  • No development reported Liver cancer

Most Recent Events

  • 07 Aug 2026 Arcus Biosciences completes phase I trial (In volunteers) in the USA (PO, Tablet) (NCT07641881)
  • 07 Aug 2026 Arcus Biosciences plans a phase I pharmacokinetic trial in healthy volunteers in August 2026 (PO) (NCT07751250)
  • 06 Aug 2026 Vanderbilt-Ingram Cancer Center in collaboration with Arcus Biosciences plans a phase 0 trial for Renal cell carcinoma (Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT07748988)

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