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Casdatifan - Arcus Biosciences

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Drug Profile

Casdatifan - Arcus Biosciences

Alternative Names: AB-521; HIF-2a inhibitor - Arcus Biosciences

Latest Information Update: 09 Jun 2025

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At a glance

  • Originator Arcus Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Renal cell carcinoma; Solid tumours
  • Phase I Cancer
  • No development reported Liver cancer

Most Recent Events

  • 09 Jun 2025 AstraZeneca plans a phase Ib/III trial for Renal cell carcinoma (Late-stage disease, First-line therapy, Combination therapy, Metastatic disease)(PO), in July 2025 (NCT07000149)
  • 28 May 2025 No recent reports of development identified for preclinical development in Liver-cancer in USA (IV)
  • 28 May 2025 No recent reports of development identified for preclinical development in Renal-cell-carcinoma in USA (IV)

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