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AB 343 - Arbutus Biopharma

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Drug Profile

AB 343 - Arbutus Biopharma

Alternative Names: AB-343 - Arbutus Biopharma; Research programme: SARS-CoV-2 Mpro inhibitors - Arbutus Biopharma/Proteros Biostructures/X-Chem; Research programme: SARS-CoV-2 nsp5 main protease inhibitors - Arbutus Biopharma/Proteros Biostructures/X-Chem

Latest Information Update: 19 Sep 2023

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At a glance

  • Originator Arbutus Biopharma; Proteros Biostructures; X-Chem
  • Developer Arbutus Biopharma
  • Class Antivirals; Small molecules
  • Mechanism of Action Coronavirus 3C-like proteinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Coronavirus infections; COVID 2019 infections

Most Recent Events

  • 11 Sep 2023 Discontinued - Preclinical for Coronavirus infections in Canada (PO) due to an unfavourable PK profile noted in the IND-enabling studies, and a potential nsp12 polymerase inhibitor
  • 11 Sep 2023 Discontinued - Preclinical for COVID-2019 infections in Canada (PO) due to an unfavourable PK profile noted in the IND-enabling studies, and a potential nsp12 polymerase inhibitor
  • 14 Mar 2023 Pharmacodynamics data from a preclinical trial in COVID-2019 infections released by Arbutus Biopharma

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