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AVB 114

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Drug Profile

AVB 114

Alternative Names: Autologous mesenchymal stromal cell coated fistula plug - Avobis Bio; AVB-114; MSC-AFP

Latest Information Update: 11 Nov 2025

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At a glance

  • Originator Mayo Clinic; W. L. Gore & Associates
  • Developer Avobis Bio; Mayo Clinic
  • Class Mesenchymal stem cell therapies
  • Mechanism of Action Cell replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Rectal fistula
  • Phase I Rectovaginal fistula
  • Research Wounds

Most Recent Events

  • 11 Nov 2025 Early research in Wounds in USA (Implant), prior to November 2025 (Avobis Bio pipeline, November 2025)
  • 11 Nov 2025 Phase-I clinical trials in Rectovaginal fistula (Treatment-experienced) (Implant), prior to November 2025 (Avobis Bio pipeline, November 2025)
  • 11 Nov 2025 Adverse events and efficacy data from a phase I trial in Rectovaginal fistula released by Avobis Bio

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