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Suzetrigine - Vertex Pharmaceuticals

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Drug Profile

Suzetrigine - Vertex Pharmaceuticals

Alternative Names: JOURNAVX; SUZ; VX-548

Latest Information Update: 31 Aug 2026

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At a glance

  • Originator Vertex Pharmaceuticals
  • Class 1 ring heterocyclic compounds; Amides; Analgesics; Ethers; Fluorinated hydrocarbons; Fluorobenzenes; Non-opioid analgesics; Pyridines; Small molecules
  • Mechanism of Action Nav1.8 voltage-gated sodium channel inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute pain
  • Phase III Neuropathic pain
  • Phase I Pain

Most Recent Events

  • 16 Jul 2026 Vertex Pharmaceuticals completes a phase I pharmacokinetic trial for Pain in the US (NCT07570069)
  • 18 Jun 2026 Suzetrigine is still in phase I development in Pain (In volunteers) in Australia (PO, Tablet) (NCT05635110)
  • 21 May 2026 Preregistration for Acute pain (In adults) in Canada (PO)

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