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Suzetrigine - Vertex Pharmaceuticals

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Drug Profile

Suzetrigine - Vertex Pharmaceuticals

Alternative Names: JOURNAVX; SUZ; VX-548

Latest Information Update: 21 Nov 2025

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At a glance

  • Originator Vertex Pharmaceuticals
  • Class 1 ring heterocyclic compounds; Amides; Analgesics; Ethers; Fluorinated hydrocarbons; Fluorobenzenes; Non-opioid analgesics; Pyridines; Small molecules
  • Mechanism of Action Nav1.8 voltage-gated sodium channel inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute pain
  • Phase III Neuropathic pain
  • Phase I Pain

Most Recent Events

  • 17 Nov 2025 Vertex Pharmaceuticals plans a phase III trial for Neuropathic pain (PO, Tablet) in November 2025 (NCT07231419)
  • 14 May 2025 Latigo Biotherapeutics plans a phase I trial for Pain in New Zealand (NCT06972212)
  • 29 Apr 2025 Vertex Pharmaceuticals completes a phase I pharmacokinetics trial in the US (PO) (NCT06820307)

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